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Updated: Oct 21, 2025

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
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アデノシンA1受容体媒介の陽性アロステリックメカニズム

Christopher J Draper-Joyce1,2, Rebecca Bhola3, Jinan Wang4

  • 1Drug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Nature
|September 9, 2021
PubMed
まとめ

この研究では,アデノシンA1受容体 (A1R) の新しいアロステリック調節剤MIPS521が導入され,ラットにおける非オピオイド性疼痛緩和効果が実証されました. ニューロパシー疼痛の標的治療の開発のための新しい戦略を強調しています.

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