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Updated: Oct 20, 2025

Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
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統合されたストレス反応は,tRNA合成酵素に関連した周辺神経病に寄与する

E L Spaulding1,2, T J Hines1, P Bais1

  • 1The Jackson Laboratory, Bar Harbor, ME 04609, USA.

Science (New York, N.Y.)
|September 13, 2021
PubMed
まとめ

移転RNA (tRNA) 合成酵素の遺伝子の支配的な変異がシャルコ・マリー・トゥース病を引き起こす. GCN2センサキナーゼと統合ストレス反応 (ISR) を阻害することで,マウスモデルにおける周辺神経病気が緩和される.

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