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関連する概念動画

Cooperative Binding of Transcription Regulators02:13

Cooperative Binding of Transcription Regulators

6.8K
Transcriptional regulators bind to specific cis-regulatory sequences in the DNA to regulate gene transcription. These cis-regulatory sequences are very short, usually less than ten nucleotide pairs in length. The short length means that there is a high probability of the exact same sequence randomly occurring throughout the genome.  Since regulators can also bind to groups of similar sequences, this further increases the chances of random binding. Transcriptional regulators form...
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DNA as a Genetic Template02:05

DNA as a Genetic Template

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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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DNA Helicases00:55

DNA Helicases

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DNA unwinding helicase enzymes are a type of motor protein. Motor proteins can translocate along filaments or polymers using energy generated from ATP hydrolysis. Helicases are involved in all the important cellular processes where DNA unwinding is required, such as DNA replication, repair, recombination, and transcription. They are present in all living organisms, but vary in their structure, function, and mechanism of action. For example, in prokaryotes, DnaB helicase binds and translocates...
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DNA Replication02:40

DNA Replication

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DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
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The DNA Helix01:16

The DNA Helix

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Overview
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Translesion DNA Polymerases02:10

Translesion DNA Polymerases

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Translesion (TLS) polymerases rescue stalled DNA polymerases at sites of damaged bases by replacing the replicative polymerase and installing a nucleotide across the damaged site. Doing so, TLS allows additional time for the cell to repair the damage before resuming regular DNA replication.
TLS polymerases are found in all three domains of life - archaea, bacteria, and eukaryotes. Of the different classes of TLS polymerases, members of the Y family are fitted with specialized structures that...
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Updated: Oct 20, 2025

Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

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協力 的 な DNA 触媒

Dallas N Taylor1,2, Samuel R Davidson3, Lulu Qian2,3

  • 1Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, United States.

Journal of the American Chemical Society
|September 15, 2021
PubMed
まとめ
この要約は機械生成です。

研究者は分子情報処理のための 新しい協働型DNA触媒を開発しました このシンプルでモジュラーなシステムは 2つの信号を用いて出力を駆動し DNAベースの回路の制御と効率を高めます

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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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関連する実験動画

Last Updated: Oct 20, 2025

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Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
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科学分野:

  • 分子生物学
  • 生物化学
  • 合成生物学

背景:

  • DNA触媒は 分子情報処理回路に不可欠です
  • アロステリック制御はDNA触媒の一時的活性化を強化する.
  • 既存のDNA触媒は限られたモジュラリティと制御を提供します.

研究 の 目的:

  • 協力的なDNA触媒を導入する
  • DNA触媒におけるアロステリック制御の方法を研究する.
  • DNAベースの分子計算の効率と強さを向上させる.

主な方法:

  • 2つの可逆反応を用いた協力的な触媒システムを設計した.
  • 反応運動を制御するために解離トーホールドを使用した.
  • アクティベーターの頑丈さを高めるため,揺れるベースペアを組み込みました.
  • 触媒の動作に利用された鎖の移動原理.

主要な成果:

  • 入力信号とアクティベータ信号の両方が出力生産を駆動する協力的触媒が実証されている.
  • 低信号濃度 (0.1xゲート濃度) でほぼ完全な出力量を示した.
  • 解離トーホールドと振動ベースペアのシステムの性能の役割を検証した.

結論:

  • 協力的なDNA触媒は分子計算のためのシンプルでモジュラーな設計を提供します.
  • このシステムは,配線移動ベースのDNA回路のためのツールキットを拡張します.
  • 設計は汎用計算とダイナミック分子システムを容易にする.