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Updated: Oct 20, 2025

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues
12:07

Sequence-specific Labeling of Nucleic Acids and Proteins with Methyltransferases and Cofactor Analogues

Published on: November 22, 2014

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ラジカルSAM酵素MiaBによるtRNAメチルチオレーションの構造的基礎

Olga A Esakova1, Tyler L Grove2, Neela H Yennawar3

  • 1Department of Chemistry, The Pennsylvania State University, University Park, PA, USA. oae3@psu.edu.

Nature
|September 16, 2021
PubMed
まとめ

この研究では,MiaB酵素が,2-メチルチオ-N6-イソペンテニラデノシン (ms2i6A) 改変を転送RNAに導入する方法を明らかにした. この研究により,S-アデノシルメチオニン (SAM) を含む2段階のメカニズムが発見され,重要な翻訳的忠誠度が得られました.

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