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Updated: May 2, 2026

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

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エンジニアリングされたIL-2部分アゴニストは,CD8+ T細胞幹細胞性を促進する

Fei Mo1, Zhiya Yu2, Peng Li1

  • 1Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.

Nature
|September 16, 2021
PubMed
まとめ

エンジニアリングされたサイトカインであるH9Tは,末端の分化を引き起こすことなく,がん免疫療法のためのCD8+T細胞を拡張します. このアプローチは幹細胞のような状態を維持し,臨床前モデルの抗腫瘍活性を強化します.

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