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関連する概念動画

Design Example: Frog Muscle Response01:14

Design Example: Frog Muscle Response

371
A student is tasked to work on an intriguing experiment involving an RL (Resistor-Inductor) circuit to study the muscle response of a frog's leg to electrical stimulation. The RL circuit plays a crucial role in this experiment, providing the means to control and measure the electrical impulses that trigger muscle contraction.
When the switch connecting the RL circuit is closed, a brief muscle contraction is observed. This is because, at a steady state, the inductor acts like a short...
371
Muscle Contraction01:15

Muscle Contraction

92.7K
 
92.7K
Muscle Coordination and Action01:24

Muscle Coordination and Action

2.3K
Muscle coordination is a complex and finely tuned process essential for smooth and purposeful movements like flexion, extension, adduction, abduction, and rotation. The human body orchestrates the actions of various muscles working in concert, each with a specific role. Four functional types describe how muscles work together: agonist, antagonist, synergist, and fixator.
Agonists
Agonist muscles, often called prime movers, are the primary muscles responsible for producing a specific movement....
2.3K
Exercise and Muscle Performance01:27

Exercise and Muscle Performance

1.8K
Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
1.8K
Generation of Action Potential in Skeletal Muscles01:24

Generation of Action Potential in Skeletal Muscles

6.6K
Every cell in the body maintains a membrane potential due to an uneven distribution of positive and negative charges across its plasma membrane. The membrane potential is measured in millivolts and quantifies the difference in charge across the membrane.
Like neurons, muscle cells are also regarded as excitable due to their capacity to change in response to stimuli, primarily due to voltage-gated ion channels embedded in their plasma membranes, which get activated by alterations in the...
6.6K
Muscles that Move the Arm01:31

Muscles that Move the Arm

3.6K
Nine muscles are involved in arm movements. Two of these, the pectoralis major and latissimus dorsi, originate from the axial skeleton and are called axial muscles. The other seven originate from the scapula and are called the scapular muscles.
The pectoralis major has two origins. Its clavicular head originates on the medial half of the clavicle. In contrast, the sternocostal head originates on the costal cartilages of ribs 1-6, the sternum, and the aponeurosis of the external oblique of the...
3.6K

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関連する実験動画

Updated: Oct 19, 2025

Author Spotlight: Bridging the Gap Between In Vivo and Ex Vivo Studies with the "Avatar" Technique to Advance Muscle Mechanics Research
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Author Spotlight: Bridging the Gap Between In Vivo and Ex Vivo Studies with the "Avatar" Technique to Advance Muscle Mechanics Research

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デザイナー AAV 筋肉アップ

Carsten G Bönnemann1

  • 1Neuromuscular and Neurogenetic Disorders of Childhood Section, Neurogenetics Branch, NINDS, NIH, Bethesda, MD, USA.

Cell
|September 17, 2021
PubMed
まとめ

誘導進化により,新しいアデノ関連ウイルス (AAV) カプシドが生まれた. このAAV9は骨格筋を標的とし この主要臓器への遺伝子治療を 改善します

科学分野:

  • 分子生物学
  • 遺伝子療法
  • ウイルス学

背景:

  • アデノ関連ウイルス (AAV) カプシドは遺伝子治療の特異性を高めるために設計されています.
  • 体の最大の臓器である 骨格筋を標的とした治療は 様々な遺伝的疾患の治療に不可欠です
  • 以前のAAV血清型は,骨格筋を効率的に標的にすることが制限されています.

研究 の 目的:

  • 骨格筋への標的遺伝子配送のための新しいAAV血清型を開発する.
  • 骨格筋のトロピズムが強化された AAV カプシドを作成するために,指向進化を使用します.

主な方法:

  • AAV9カプシドタンパク質を修正するために,指向進化技術を使用した.
  • インテグリン結合モチーフを含むRGD- (アルギニン・グリシン・アスパルティック酸) を含有する変種に選択された.
  • AAV9カプシドのハイパー変性領域内の焦点を合わせた変化

主要な成果:

  • 骨格筋のトロピズムが強化されたAAV9カプシドを生成しました.
  • エンジニアリングされたカプシドにはRGDを含むインテグリン結合ヘプタマーが含まれています.
  • この変更により,最大の人間の臓器の標的が改善されます.

さらに関連する動画

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage
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Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

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An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
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An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

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関連する実験動画

Last Updated: Oct 19, 2025

Author Spotlight: Bridging the Gap Between In Vivo and Ex Vivo Studies with the "Avatar" Technique to Advance Muscle Mechanics Research
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Author Spotlight: Bridging the Gap Between In Vivo and Ex Vivo Studies with the "Avatar" Technique to Advance Muscle Mechanics Research

Published on: August 18, 2023

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Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage
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Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Published on: August 31, 2022

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An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles
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An Emerging Target Paradigm to Evoke Fast Visuomotor Responses on Human Upper Limb Muscles

Published on: August 25, 2020

4.4K

結論:

  • 組織特有のAAVベクトルの作成のための効果的な戦略です.
  • 新しく設計されたAAV9変種は 骨格筋に誘導された遺伝子治療の 可能性を示しています
  • この進歩は筋肉関連の疾患に対する 遺伝子療法の有効性を大幅に改善する可能性があります