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Updated: Oct 19, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses

Published on: May 6, 2019

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抗原の優位性の階層は,腫瘍におけるTCF1+原始性CD8T細胞のフェノタイプを形成する

Megan L Burger1, Amanda M Cruz2, Grace E Crossland1

  • 1David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell
|September 17, 2021
PubMed
まとめ

腫瘍の新抗原反応は安定したMHC結合物質によって支配される. 弱い抗原に反応するT細胞のサブセットは,最初は免疫療法に有望であったが,機能不全であり,免疫チェックポイントのブロックに反応しないことが判明した.

キーワード:
CCR6 についてCD8 T細胞TCF1 についてTc17 についてチェックポイントの封鎖免疫優位性について肺がんネオアンチゲンワクチン

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