1年間の運動訓練により,B段階の心不全の患者で異常な左心室筋硬直が逆転する
Michinari Hieda1,2,3, Satyam Sarma1,2, Christopher M Hearon1,2
1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (M.H., S.S., C.M.H., J.P.M., K.A.D., M.S., D.P., S.L., M.M., B.D.L.).
Circulation
|September 20, 2021
まとめ
高強度運動は,左心室 (LV) 筋硬化と心臓のバイオマーカーの上昇を有意に減少させた. これは運動が将来の心不全を予防し 排泄分子が保たれることを示唆しています
科学分野:
- 心臓病科
- 運動 生理学
- 心不全 の 研究
背景:
- 左心室 (LV) 縮と心臓のバイオマーカーが上昇した中年患者は,保存されたエジェクション分数 (HFpEF) による心不全のリスクが増加します.
- 健康な老化において,長期の運動トレーニングは,LVの硬化を逆転させることが知られているが,高リスク患者にその効果は不明である.
研究 の 目的:
- 1年間の長期の運動が,心筋縮と心筋縮のバイオマーカーの上昇を正常化できるかどうかを調べる.
- HFpEFのリスクが高い人の心臓機能に対する運動の影響を評価する.
主な方法:
- 潜在的ランダム化対照試験で,LV増幅と心臓バイオマーカー値上昇の46人の患者が参加した.
- 患者は1年間の高強度運動訓練 (n=30) または注意コントロールグループ (n=16) に割り当てられました.
- 前負荷操作の際に右心経導管と3Dエコーカーディオグラフィーを用いて,LVの末端の腹圧と体積の関係から硬さを計算した.
主要な成果:
- 1年間の運動トレーニングは,対照群と比較して,心肺呼吸能力 (VO2max) を21% (P< 0. 0001) 増加させた.
- 運動訓練は,対照群と比較して,LV心筋の硬さを有意に減少させた (ベースライン0. 062±0. 020から0. 031±0. 009,P=0. 001).
- コントロール群では,VO2maxやLV心筋硬直の有意な変化は見られなかった.
結論:
- 1年間の高強度運動は,高強度筋縮と心臓バイオマーカーの上昇を伴う患者の心臓筋縮を効果的に軽減しました.
- 運動訓練は,この高リスク集団において,エジェクション分子が保存された心不全の発生に対する保護策を提供することができる.
- クリニカルトライアルズ.govのID: NCT03476785
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