一般人群における亜臨床冠動脈動脈硬化症の流行
Göran Bergström1,2, Margaretha Persson3,4, Martin Adiels5
1Department of Molecular and Clinical Medicine (G. Bergström, E.B., O.A., B.F., O.H., A.R.), University of Gothenburg, Sweden.
Circulation
|September 20, 2021
まとめ
静かな冠動脈動脈硬化症は,冠動脈計算機断層検査 (CCTA) によって検出された一般人群で一般的です. 高度の冠動脈結晶度 (CAC) 値は,有意な狭窄を示しますが,CACスコア0は動脈硬化症を排除しません.
科学分野:
- 心臓病科
- 放射線科
- 公衆衛生
背景:
- 冠動脈硬化症の検出は,冠動脈計算機断層検査 (CCTA) と冠動脈結石化 (CAC) のスコアリングによって予防を導くことができます.
- 一般集団における動脈硬化症の流行と特徴を理解することは極めて重要です.
研究 の 目的:
- CCTAを使用して冠動脈動脈硬化症の流行,重症度,および特徴を決定する.
- 一般集団におけるCCTAで検出された動脈硬化症とCACスコアの関連性を評価する.
- 流行の推定値の外部有効性を評価する.
主な方法:
- SCAPIS研究のために50歳から64歳の30154人を募集した.
- 既知の冠動脈疾患のない患者にCCTAとCAC画像検査を行った.
- 冠動脈動脈硬化症のCACスコアと視覚的なCCTAスコア (狭窄症の重度)
主要な成果:
- 25, 182人の参加者の42. 1%がCCTAで検出された動脈硬化症; 5. 2%が著しい狭窄症 (≥50%).
- 女性では動脈硬化の発症が10年遅れており,年齢やCACスコアに伴い,罹患率は増加した.
- CAC > 400 の個人は動脈硬化症 (45. 7% は有意な狭窄症),CAC 0 の個人は動脈硬化症であった.
結論:
- 静かな冠動脈動脈硬化症は,既知の疾患のない一般人群で一般的です.
- 高CACスコアは有意な狭窄と相関しているが,CAC0は,特にリスクの高い個体では,動脈硬化症を排除しない.
- CCTAは,アテロスクレロスの負担と一般人口のCACとの関係に関する貴重な洞察を提供します.
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