TIRシグナリングのアクティベーションは,パターン誘発免疫を強化します
Hainan Tian1, Zhongshou Wu1,2, Siyu Chen1,3,4
1Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada.
Nature
|September 20, 2021
まとめ
トール/インタールイキン-1受容体 (TIR) のシグナリングは,植物におけるパターン誘発免疫 (PTI) に極めて重要です. TIRシグナリングを活性化すると,PTI応答を刺激することで病原体に対する植物防御を強化します.
科学分野:
- 植物免疫
- 分子植物病原体相互作用
- セルラー信号
背景:
- 植物の免疫反応はパターン認識受容体 (PRR) と核酸結合レウシン豊富なリピート受容体 (NLR) に依存する.
- Toll/インタールイキン-1受容体 (TIR) ドメインを持つNLRは,NADase活性を通して防御を活性化します.
研究 の 目的:
- パターン誘発免疫 (PTI) のTIRシグナル活性化の役割を調査する.
- 病原菌に対する植物防御に対するTIR信号の貢献を理解する.
主な方法:
- PTI応答におけるTIRシグナル伝達変異体の分析
- NLRレベルが低下したプラントでの PTI の評価
- PTIエリシター治療によるTIRドメインを含むタンパク質の遺伝子発現分析
主要な成果:
- TIRシグナリング変異体はPTI反応を弱め,病原体の耐性を低下させた.
- NLRレベルが低い工場では PTIが危険にさらされた.
- PTIエリクターは,TIRドメインタンパク質をコードする遺伝子を迅速に誘導し,PTI中にTIRシグナリングの活性化を示唆した.
結論:
- TIRシグナリングの活性化は,強いパターン誘発免疫のために不可欠です.
- TIRシグナリングは,PTI時のプラント防衛を強化するための重要なメカニズムとして機能します.
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