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Updated: Oct 19, 2025

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
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強化されたポリメラーゼ互換性を持つ新しい1,5-非置換トリアゾールDNA脊髄ミミク

Sven Epple1, Aman Modi1, Ysobel R Baker1

  • 1Chemistry Research Laboratory, University of Oxford, Oxford, OX1 3TA, U.K.

Journal of the American Chemical Society
|September 21, 2021
PubMed
まとめ

トリアゾール結合 (TLs) は,合成生物学におけるオリゴヌクレオチドの骨格を模倣する. 新しいTL2アナログは,優れたDNAポリメラーゼ複製運動性と生物互換性を示し,将来の人工核酸設計を導く.

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