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Updated: Oct 19, 2025

Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks
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Tools to Study the Role of Architectural Protein HMGB1 in the Processing of Helix Distorting, Site-specific DNA Interstrand Crosslinks

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高流動性のグループボックス1 (HMGB1) のO-GlcNAcylationは,DNA結合およびDNA損傷処理活動を変化させる

Aaron T Balana, Anirban Mukherjee1, Harsh Nagpal2

  • 1Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Dell Pediatric Research Institute, 1400 Barbara Jordan Boulevard, Austin, Texas 78723, United States.

Journal of the American Chemical Society
|September 21, 2021
PubMed
まとめ

タンパク質O-GlcNAcylationはHMGB1を改変し,DNA結合および修復機能に影響を与える. この糖変異は,損傷したDNAのHMGB1オリゴメリゼーションを強化し,DNA修復を阻害し,O- GlcNAcを癌変異と結びつける可能性があります.

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