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Updated: Oct 19, 2025

Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
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Kv4チャネル複合体のゲート調節の構造的基礎

Yoshiaki Kise1, Go Kasuya2, Hiroyuki H Okamoto3

  • 1Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan. yoshiaki.kise@bs.s.u-toyko.ac.jp.

Nature
|September 23, 2021
PubMed
まとめ

構造的な洞察は,Kvチャネル相互作用タンパク質 (KChIPs) とディペプチジルペプチダゼ関連タンパク質 (DPPs) がKv4チャネル機能を調節する方法を明らかにします. KChIP1はS6ヘリクスを安定させ,不活性化を防止し,DPP6Sは電圧感知領域を安定させ,チャネルゲートを加速します.

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