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Updated: Oct 19, 2025

Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes
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Single-Molecule Fluorescence Visualization of DNA Polymerase Dynamics at G-Quadruplexes

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トポロジー依存リガンド結合に基づくG四重複のDNA複製の化学的調節

Shuntaro Takahashi1, Anita Kotar2, Hisae Tateishi-Karimata1

  • 1FIBER (Frontier Institute for Biomolecular Engineering Research), Konan University, 7-1-20 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.

Journal of the American Chemical Society
|September 23, 2021
PubMed
まとめ

研究者は,トポロジーを選択するグアニン四重複 (G4) リガンドを作成するための新しい方法を開発しました. これらのリガンドはDNA複製を調節することで遺伝子発現を制御し,癌や神経変性疾患の治療に潜在力を提供します.

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