エピジェネティック・エイジと心房細動の発生リスク
Jason D Roberts1,2, Eric Vittinghoff3, Ake T Lu4
1Population Health Research Institute (J.D.R., P.M-S., G.P.).
Circulation
|September 30, 2021
まとめ
エピジェネティック・エイジング・アクセラレーション (EAA) は,心房細動のリスクの増加と関連しており,これは,年齢に関係なく,生物学的老化が心臓の健康に影響を及ぼすことを示唆している. これらの老化プロセスは修正可能であり,潜在的な治療目標を提供します.
科学分野:
- 遺伝学
- エピジェネティクス
- 心臓病科
背景:
- 慢性的な年齢は心房細動 (AF) の主要な危険因子ですが,その根本的なメカニズムは不明です.
- エピジェネティック・モディフィケーションは時間的年齢を予測し,偏差 (エピジェネティック・エイジング・アクセラレーション,EAA) は加速した生物学的老化を示す可能性があります.
研究 の 目的:
- エピジェネティック年齢測定値と心房細動 (AF) の発生率との関連を調査する.
主な方法:
- 3つの集団ベースのコホートから得られたデータを用いて,4つの表遺伝子クロック (Horvath,Hannum,DNAm PhenoAge,DNAm GrimAge) とDNAm PAI-1を測定した.
- コックスモデルとメタアナリシスを用いて,インシデントAFのリスクを評価し,メンデルのランダム化分析で因果関係を調べた.
主要な成果:
- エピジェネティック・エイジング・アクセラレーション (EAA) 測定値,特にDNAm GrimAgeとDNAm PhenoAgeは,年代的年齢と他のリスク要因を調整した後に,発生したAFの危険性が著しく高かった.
- DNAm GrimAgeとDNAm PhenoAgeのEAAの5年増加は,それぞれ19%と15%の高いAF発生率と相関していました.
- メンデルのランダム化分析は統計的に有意な因果関係を確立しなかった.
結論:
- EAAとインシデント AFの間の調整された関連は,生物学的老化が時間的年齢とは独立した役割を果たすことを示唆しています.
- 特定された老化プロセスは修正可能であり,AFの予防や介入のための潜在的な道を示します.
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