サーカディアン・オートファギーは iTRFによる長寿を促す
Matt Ulgherait1, Adil M Midoun2, Scarlet J Park3,4
1Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Nature
|September 30, 2021
まとめ
断続的な時間制限の餌 (iTRF) は,生理時調節された自己消化を促進することで,寿命を延ばし,老化マーカーを遅らせます. これは同様の介入によって人間に与える 潜在的な健康効果を示唆している.
科学分野:
- ゲロントロジー
- クロノバイオロジー
- 分子生物学
背景:
- 時間制限の食事 (TRF) は,食事の摂取を特定の日数時間に制限する食事戦略であり,抗老化介入の可能性を示しています.
- TRFの健康上の利点の基礎となる分子メカニズム,特に昼夜リズムとの関連は,ほとんど未知のままです.
研究 の 目的:
- ドロソフィラの寿命と老化マーカーの間歇的な時間制限の餌 (iTRF) の影響を調査する.
- iTRFによる健康上の利益に関与する分子経路,特に昼夜調節と自を明らかにする.
主な方法:
- ドロソフィラの断続的な時間制限の餌 (iTRF) を開発し,実施した.
- 寿命の延長と筋肉と腸の老化マーカーの出現を評価した.
- iTRFの効果を媒介するサーカディアン調節とオートファギーの役割を分析し,オートファギーの誘導の特定のタイミングを含めた.
主要な成果:
- iTRFはハエの寿命を大幅に延長し 老化マーカーを遅らせました
- iTRFは,日経調節による遺伝子転写を強化した.
- iTRFによる寿命の延長は,循環器の調節と自己消化の両方に依存していた.
- 夜間限定のオートファジー誘導は必要で,寿命延長には十分であったが,昼間限定の誘導はそうではなかった.
結論:
- サーカディアン調節されたオートファギーは,ドロソフィラの iTRF の健康上の利点の基礎にある重要なメカニズムです.
- これらの発見は,日経調節された自閉症を標的とした介入が,抗老化効果を提供し,ヒトの寿命を延ばす可能性があることを示唆しています.
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