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臓がんにおける空間的に限定されたサブ腫瘍微環境

Barbara T Grünwald1, Antoine Devisme2, Geoffroy Andrieux3

  • 1Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada.

Cell
|October 13, 2021
PubMed
まとめ

臓がんにおける腫瘍微環境 (TME) の異質性はランダムではない. 腫瘍の免疫,進行,化学療法への反応に影響する 異なる"サブTME"を 特定しました

キーワード:
癌に関連した線維芽細胞臓がん患者からのオーガノイドプロテオミクスストロマの異質性システム生物学トリートメント抵抗腫瘍の微小環境

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The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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