生命 の 息: 心臓 疾患 と 発達 的 低酸素 の 関係
1Department of Physiology, Development, and Neuroscience; The Barcroft Centre; Cambridge Cardiovascular British Heart Foundation Centre for Research Excellence; and Cambridge Strategic Research Initiative in Reproduction, University of Cambridge, UK.
Circulation
|October 25, 2021
まとめ
妊娠中の胎児の慢性低酸素は子孫を増やす
科学分野:
- 心血管科学と健康と病気の発達起源 (DOHaD)
背景:
- 心臓病は死亡の主な原因で 産前の影響が認識されつつあります
- 胎児の慢性低酸素症のような 妊娠中の不良症状は 将来の子孫における 心血管疾患のリスクと関連しています
- これらの発達の起源を理解することは 予防戦略にとって極めて重要です
研究 の 目的:
- 胎児の心臓血管発達に対する慢性的な胎児低酸素の影響を検討する.
- 産前低酸素と成人の心血管疾患の 関連性を調べる
- 低酸素症による妊娠の潜在的な治療策について議論する.
主な方法:
- 胎児の低酸素を検査するヒトの研究と動物モデル (ネズミ,鳥,羊) のレビュー
- 酸化ストレスとミトコンドリア機能を含む分子経路に焦点を当てます
- 心血管疾患の発達の起源に関する証拠の統合
主要な成果:
- 慢性的な胎児低酸素は 短期的にも長期的にも 胎児の心血管系に影響します
- 産前低酸素は酸化ストレスの増加と関連しています.
- この分子結合は,成人の子孫において心血管疾患のリスクを高めます.
結論:
- 胎児の慢性低酸素症は 後に発症する心臓病の重要な危険因子です
- ミトコンドリアを標的とした抗酸化療法が 臨床介入の有望性を示しています
- 妊娠中の予防策は,将来の心血管疾患のリスクを軽減することができます.
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