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Updated: Oct 15, 2025

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays
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Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

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COVID-19における不適切なTGFβ応答は,NK細胞の抗ウイルス機能を制限する

Mario Witkowski1,2,3, Caroline Tizian4,5, Marta Ferreira-Gomes6

  • 1Laboratory of Innate Immunity, Institute of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Campus Benjamin Franklin, Berlin, Germany. mario.witkowski@charite.de.

Nature
|October 25, 2021
PubMed
まとめ

自然キラー (NK) 細胞はSARS-CoV-2を制御するのに役立ちますが,重度のCOVID-19はそれらの機能を損なうのです. 変形成長因子β (TGFβ) の過剰生産は,重症の場合NK細胞の活性とウイルスのクリアランスを抑制する.

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