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Updated: Oct 15, 2025

Manipulation of Gene Function in Mexican Cavefish
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Manipulation of Gene Function in Mexican Cavefish

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スタウディンガー還元によるMorpholino Antisense Oligonucleotide機能の小分子制御

Kristie Darrah1, Joshua Wesalo1, Bradley Lukasak1

  • 1Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.

Journal of the American Chemical Society
|October 27, 2021
PubMed
まとめ

研究者らは精密な遺伝子破壊のために,小分子トリガードケージモルフォリノアンチセンス剤 (cMO) を開発した. これらの新薬は 遺伝子発現の時間的・空間的な制御を可能にし 胚の発達の研究のための 進歩的なツールとなっています

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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