既定の心血管疾患または糖尿病を有する患者の腎臓機能全般におけるIcosapent Ethylの効果: REDUCE- IT RENAL
PubMedで要約を見る
まとめ
この要約は機械生成です。Icosapent ethylは慢性腎臓病 (CKD) とトリグリセリド値上昇の患者の心血管疾患を効果的に軽減しました. 腎機能低下を含む,すべての推定グルメルフィルタレーションレート (eGFR) カテゴリーにおいて,治療は一貫した効果を示した.
科学分野
- 心臓病科
- 腎臓科
- 薬理学について
背景
- 慢性腎臓病 (CKD) は,心血管疾患 (CVD) または糖尿病の患者における有害な結果と関連しています.
- 標準的なCVD薬は腎機能障害の患者ではしばしば効果が低い.
研究 の 目的
- REDUCE- IT試験において,異なったレベルの腎機能を有する患者におけるicosapent ethylの有効性を分析する.
- イコサペントエチルの心血管疾患への影響を評価するために,異なる推定球膜過濾率 (eGFR) カテゴリーで.
主な方法
- REDUCE- IT試験では,トリグリセリド値が上昇し,心血管疾患のリスクが高いスタチンを投与した患者を,アイコサペントエチルまたはプラセボにランダムに分けました.
- 主要および次要コンポジットエンドポイントに対する治療効果を評価するために,患者さんは基値eGFRによって層分けされました.
主要な成果
- イコサペントエチルは,すべてのeGFRカテゴリーにおいて,主および二次複合性心血管のエンドポイントを一貫して低下させた.
- eGFR < 60 mL·min−1. 73 m−2 の患者は,プライマリーエンドポイントの絶対リスクの減少が最大であった (HR,0. 71).
- 最低のEGFR群では数値的に高い割合にもかかわらず,心房動/心房動および重度の出血の割合は,eGFR群全体で類似していました.
結論
- イコサペントエチルは,心血管の危険因子と異なるレベルの腎臓機能を有する患者の血栓不全を軽減する効果を示した.
- イコサペントエチルの効果は,eGFRの全スペクトルで観察され,CKD患者での使用を裏付けました.
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