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Updated: Oct 15, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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病変の予測は,進化データによる深層の生成モデルによって行われます.

Jonathan Frazer1, Pascal Notin2, Mafalda Dias1

  • 1Marks Group, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.

Nature
|October 28, 2021
PubMed
まとめ

新しい計算モデルであるEVE (変異効果の進化モデル) は,病気のラベルなしでタンパク質変異の病原性を予測します. このアプローチは,未知の重要性を持つ数百万の遺伝的変異を分類する既存の方法と補助器具を上回ります.

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