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Updated: Oct 15, 2025

Bimolecular Fluorescence Complementation
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ニューロフィブロミンイソフォーム2の構造は,異なる機能的状態を明らかにする

Andreas Naschberger1,2, Rozbeh Baradaran1, Bernhard Rupp3,4

  • 1SciLifeLab, Department of Biochemistry and Biophysics, Stockholm University, Solna, Sweden.

Nature
|October 28, 2021
PubMed
まとめ

ニューロフィブロマトーシス1型 (NF1) は,ニューロフィブロミン (Nf1) タンパク質の機能に影響するNF1遺伝子の変異によって引き起こされます. 構造分析により,NF1は閉じた状態と開かれた状態で存在し,NF1と癌の発達を理解するために不可欠です.

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