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Updated: Oct 15, 2025

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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ベラクトシンとホルモマイシンをバイオシンセシスする際のステレオダイバーゲントのニトロサイクロプロパン形成

Shotaro Shimo1, Richiro Ushimaru1,2,3, Alicia Engelbrecht4

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|October 28, 2021
PubMed
まとめ

この研究では,BelK,HrmI,BelL,HrmJの酵素が天然製品に含まれるユニークなサイクロプロパンを含むアミノ酸を合成する方法を明らかにしました. これらの酵素は,3−−−ニトロcyclopropyl) アラニンの形成中のステレオ化学を制御する.

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