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Icosapent Ethylは,前回の冠動脈バイパス移植歴のある患者の血栓不全を軽減する: REDUCE- IT CABG
Subodh Verma1, Deepak L Bhatt2, Ph Gabriel Steg3
1Montreal Heart Institute, Université de Montréal, Quebec, Canada (J-C.T.).
Circulation
|October 28, 2021
PubMed で要約を見る
まとめ
冠動脈バイパス移植歴のある患者では,イコサペントエチルにより有意に減少した. この介入は 手術後の残留心血管リスクの管理に不可欠な選択肢です
科学分野:
- 心臓病科
- 臨床試験
- 薬剤療法
背景:
- 冠動脈バイパス移植 (CABG) の後,医学と外科の進歩にもかかわらず,有意な残留性缺血リスクが持続しています.
- 低密度の脂質タンパク質コレステロールと高トリグリセリデミアの患者は,しばしば残留心血管疾患を経験します.
- このリスクを軽減する効果的な治療法を特定することは 患者の治療結果を改善するために極めて重要です
研究 の 目的:
- 過去に冠動脈バイパス移植 (CABG) を受けた患者におけるicosapent ethylの有効性と安全性を評価する.
- この特定の患者のサブグループにおけるイコサペントエチルの原始的および二次的な有効性評価値の低下への影響を評価する.
- CABG後の患者における最初のおよび再発した不血症の効果を分析する.
主な方法:
- REDUCE- IT試験の冠動脈バイパス移植歴のある1837人の患者のサブグループの分析.
- イコサペントエチルまたはプラセボの1日4gを投与する患者のランダム化.
- 主要有効性エンドポイント (心血管死,心筋梗塞,脳卒中,冠動脈再循環,不安定性胸痛入院) と主要二次エンドポイント (心血管死,心筋梗塞,脳卒中) の比較
主要な成果:
- イコサペントエチルは,プラセボと比較して,プライマリエンドポイント (HR,0. 76; P=0. 004) と鍵となる二次エンドポイント (HR,0. 69; P=0. 001) を有意に低下させた.
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