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Updated: May 12, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

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超強力で選択的なヒトβ因子XIIaのサイクルペプチド阻害剤

Wenyu Liu1, Simon J de Veer2,3, Yen-Hua Huang2,3

  • 1Department of Chemistry, Graduate School of Science, The University of Tokyo, Tokyo, 113-0033, Japan.

Journal of the American Chemical Society
|November 1, 2021
PubMed
まとめ

植物からのサイクルペプチドであるサイクロチドは,mRNAディスプレイを使用して強力なFXIIa阻害剤に設計されました. 鉛阻害剤であるcMCoFx1は高い選択性を示し,凝固障害の治療の可能性を示しています.

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