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Updated: Oct 14, 2025

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

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遺伝子毒性C8-アリラミノ-2'-デオキシアデノシンは,DNAインターストランドクロスリンクを誘導する潜在的アルキル化剤として作用する

Aaron L Rozelle1,2, Seongmin Lee1

  • 1Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, United States.

Journal of the American Chemical Society
|November 2, 2021
PubMed
まとめ

ポリサイクリックアロマティックアミンは,酸化ストレス下での8 - アリラミノ-2'-デオキシアデノシン病変を酸化することによって,新しい遺伝子毒性メカニズムを明らかにすることによって,DNAの鎖間クロスリンク (ICL) を引き起こします.

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