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Updated: Oct 14, 2025

Isolation of CA1 Nuclear Enriched Fractions from Hippocampal Slices to Study Activity-dependent Nuclear Import of Synapto-nuclear Messenger Proteins
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RNA は核内の空間区画の形成を促す

Sofia A Quinodoz1, Joanna W Jachowicz1, Prashant Bhat2

  • 1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Cell
|November 5, 2021
PubMed
まとめ

新しいRNA & DNA SPRITE技術は,非コーディングRNAが核の領域を形成する方法を明らかにしています. これらのRNA領域は DNAの構造,遺伝子発現,核の重要な機能を制御する 調節体を採用します

キーワード:
RNA 処理カジャル体クロモセンターヒストンロカス体lncRNAs についてncRNAs について核物質核構造

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
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The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
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