癌の生存者における心臓血管バイオマーカーの利用の将来的展望: アメリカ心臓協会の科学的な声明
Circulation
|November 10, 2021
まとめ
精密医療は 癌の生存率を向上させ 心血管の健康を 決定的に改善します この声明は,パーソナライズされた心臓腫瘍学のためのバイオマーカー,イメージングおよびデータの統合を調査し,がん治療中の心臓血管リスク評価とモニタリングにおける現在のギャップに対処します.
科学分野:
- 心臓腫瘍学
- バイオマーカーの発見
- 精密医療
背景:
- 精密医療と免疫療法によって 癌の生存率が向上しています
- 心血管の健康は 今や がん患者の全般的な健康状態の 決定的な要因となっています
- 伝統的な組織診断は癌の治療に不可欠ですが,心臓腫瘍学では限られています.
研究 の 目的:
- 心臓腫瘍学における心血管組織診断の全身的なアプローチを探求する.
- 心臓腫瘍学の様々な臨床シナリオに このアプローチをパーソナライズする
- 現在の心血管バイオマーカーの応用における限界と知識のギャップを解決する.
主な方法:
- 癌患者の心血管バイオマーカーに関する文献レビュー
- 循環するバイオマーカー,マルチモダリティーイメージング,パノミクス,デジタル生理学的データを統合する探索.
- 心臓腫瘍学におけるバイオマーカー概念の広範な定義
主要な成果:
- リスクの階層化,モニタリング,損傷の検出のための心血管バイオマーカーの使用における制限と知識のギャップを特定した.
- 癌の交差点における心臓血管バイオマーカーに関する現在の文献を要約した.
- 心臓腫瘍学における体系的,個別的なアプローチの必要性を強調した.
結論:
- 心臓がん診断の課題を克服するために,多様なデータストリームを統合したシステムアプローチが提案されています.
- このアプローチのパーソナライゼーションは 多様な患者集団や癌の種類や治療法にとって 鍵となるものです
- バイオマーカーの発見,検証,臨床応用における 協調的な努力は,心臓腫瘍学ネクサスで必要である.
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