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Updated: Oct 13, 2025

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KRAS ((G12C) 抑制に対する耐性に関連した様々な変化

Yulei Zhao1, Yonina R Murciano-Goroff2, Jenny Y Xue1,3

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer, New York, NY, USA.

Nature
|November 11, 2021
PubMed
まとめ

肺がんにおける KRAS (G12C) 阻害剤に対する耐性は,新しい KRAS,NRAS,または BRAF 変異によって発生することがあります. ERKシグナリングをターゲットにすることで,この既得抵抗性を克服し,患者の改善のために組み合わせ治療を提案することができます.

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