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Updated: Oct 13, 2025

Analyzing Protein Architectures and Protein-Ligand Complexes by Integrative Structural Mass Spectrometry
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HER2-HER3-NRG1β複合体の構造は,ダイナミックな二重体インターフェースを示している

Devan Diwanji1,2, Raphael Trenker1, Tarjani M Thaker1,3

  • 1Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.

Nature
|November 11, 2021
PubMed
まとめ

研究者達は,がんの成長に不可欠な HER2-HER3複合体の構造的ダイナミクスを発見しました. これらの相互作用を理解することで,トラストズマブのような変異と治療がHER2-HER3二重体にどのように影響するか明らかになります.

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