自閉症に関連する食事の好みは,自閉症と腸内微生物の関連を媒介する
Chloe X Yap1, Anjali K Henders2, Gail A Alvares3
1Mater Research Institute, The University of Queensland, Woolloongabba, Queensland 4102, Australia; Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia; Cooperative Research Centre for Living with Autism (Autism CRC), Long Pocket, Queensland 4068, Australia.
Cell
|November 12, 2021
まとめ
自閉症スペクトル障害 (ASD) は腸内微生物群の違いと直接関連していません. 代わりにASDに対する関心は 食事の多様性と相関し 腸内微生物と便の一貫性に影響します
科学分野:
- 微生物群の研究
- 神経発達障害
- 自閉症スペクトル障害 (ASD)
背景:
- ASDにおける腸内微生物の役割に対する関心が高まっています
- 以前の研究には 効果がなく 混同因子の分析も 徹底していませんでした
- 腸内微生物とASDの関連性について 徹底的な調査が必要です
研究 の 目的:
- 腸内微生物の構成とASDの診断との関連を調査する
- ASDにおける微生物群の違いに影響を与える 潜在的な混同因子を調べる
- ASD,食事,腸内微生物の関係を明らかにする.
主な方法:
- オーストラリアの自閉症バイオバンクとクイーンズランド州双子の青少年脳プロジェクトの参加者を用いた大規模な便のメタゲノミクス研究 (n=247).
- ASDの診断と関連した微生物組成の分析
- 年齢,食事摂取量,便の一貫性を検出する統計力.
主要な成果:
- ASDの診断と腸内微生物の組成との間には 軽微な直接的な関連性が見つかりました
- ASDに関連した制限された関心は,より少ない多様性のある食事に関連しています.
- 微生物の多様性の減少と,食事による摂取の制限と関連した,より緩やかな便の一貫性.
- 微生物群と年齢,食事,便の一致性との関連が強く検出されました.
結論:
- ASDの腸内微生物群の違いは,診断上の特徴に関連した食事の好みに二次的かもしれません.
- ASDにおける腸内微生物の直接的な因果関係には 証拠はありません.
- マイクロバイオームがASDの発症を促すという主張には注意が必要です.
関連する概念動画
01:19Autism Spectrum Disorder
483
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
483
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
451
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
451
01:23Anatomy of the Intestines
84.1K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
84.1K
01:17Irritable Bowel Syndrome I: Introduction
543
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
543
01:26Modeling in Therapy
168
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
168
01:50What is Monogastric Digestion?
72.9K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
72.9K