関連する実験動画

Updated: Oct 13, 2025

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction
08:01

Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction

Published on: November 20, 2018

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ネズミの生殖系における再結合ホットスポットでのデノボの削除と重複

Agnieszka Lukaszewicz1, Julian Lange2, Scott Keeney3

  • 1Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Cell
|November 18, 2021
PubMed
まとめ

メオシスは通常,DNAの二重鎖の断裂 (DSB) を修復しますが,2つの密接なDSBを結合することによって欠損を形成することができます. この突然変異は,DSBの形成が乱され,ゲノムの進化に影響を与えると増加します.

キーワード:
ATM についてNHEJ についてSPO11 ダブルストランドブレイクコピー番号の変種削除ダブルカット染色体外サークルゲルムライン変異ミエオティックDSBタンドム複製

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