COVID-19で入院した患者のアスピリン (RECOVERY):ランダム化,制御,オープンラベル,プラットフォーム試験
Lancet (London, England)
|November 20, 2021
まとめ
アスピリンは入院したCOVID-19患者の28日間の死亡率を低下させなかった. しかし,アスピリンの使用は,生存して退院する患者のわずかな増加と,重度の出血の増加とともに,血栓的事件の減少と関連していました.
科学分野:
- 臨床医学
- 感染症
- 薬理学について
背景:
- アスピリンの抗血栓性により,COVID-19治療の可能性があることが示唆されました.
- RECOVERY試験は,入院したCOVID-19患者のアスピリンの有効性と安全性を調査した.
研究 の 目的:
- COVID-19で入院した患者のアスピリンの有効性と安全性を評価する.
- アスピリンの28日間の死亡率と他の臨床結果への影響を決定する.
主な方法:
- ランダム化され,制御され,オープンラベルで実施されたプラットフォーム試験で,英国177の病院および国際的に14892人の適格な患者が参加した.
- 患者は1対1でアスピリン (150 mg/ 日) または通常の治療を受けるように割り当てられました.
- 主なアウトカムは28日間の死亡率で,治療の意図による分析が行われました.
主要な成果:
- アスピリンと通常治療群の28日間の死亡率に有意な差はありません (17%対17%;率比0. 96).
- アスピリン群は,入院期間が短く,28日以内に生存退院率が高かった (75%対74%).
- アスピリンの使用は,血栓性イベントを減少させましたが,主要な出血イベントを増加させました.
結論:
- アスピリンは,入院したCOVID-19患者の28日間の死亡率や機械呼吸器/死亡リスクを軽減しませんでした.
- アスピリンは28日以内の生存率のわずかな増加と関連していました.
- この研究では,アスピリンの使用で血栓症の減少と出血のリスクの増加とのトレードオフが強調されています.
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