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Updated: Oct 12, 2025

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協力的な分子間腫瘍遺伝子の発現を駆動する

King L Hung1, Kathryn E Yost1, Liangqi Xie2,3,4

  • 1Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|November 25, 2021
PubMed
まとめ

エクストラクロモソームDNA (ecDNA) ハブが集まって,腫瘍遺伝子ががんで過剰発現することを可能にします. BRD4と呼ばれるタンパク質が これらのハブと結合し それを阻害すると 腫瘍遺伝子の転写が減り 癌治療の標的となる可能性があります

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