関連する実験動画

Updated: Oct 12, 2025

Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches
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Analysis of Somatic Hypermutation in the JH4 intron of Germinal Center B cells from Mouse Peyer's Patches

Published on: April 20, 2021

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Fam72aは,抗体多様化中に誤りやすいDNA修復を強制する

Mélanie Rogier1,2,3,4, Jacques Moritz1,2,3,4, Isabelle Robert1,2,3,4

  • 1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.

Nature
|November 25, 2021
PubMed
まとめ

科学者はFAM72Aが 免疫反応に不可欠なDNA修復経路を 制御することを発見しました uracil DNA glycosylase (UNG2) と相互作用することで,FAM72AはDNA修復を制御し,B細胞受容体の多様化に影響を与え,がんの発症に潜在的に影響を与える.

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