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アナプラスティックリンパ腫キナーゼ受容体の活性化メカニズム

Andrey V Reshetnyak1, Paolo Rossi1, Alexander G Myasnikov1

  • 1Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Nature
|November 25, 2021
PubMed
まとめ

ALKAL1/ 2リガンドによるアナプラスティックリンパ腫キナーゼ (ALK) 受容体の活性化にはユニークなメカニズムが含まれています. 構造研究は,ALK受容体の二分化と活性化がどのように起こるかを明らかにし,多様な受容体チロシンキナーゼ活性化経路を強調しています.

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