O-Glycosylationは,アミロイド-βを誘導して,分解に脆弱な新しいフィブリルポリモルフを形成する

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Updated: Oct 11, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

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Dangliang Liu1,2, Qijia Wei1,2, Wencheng Xia3,4

  • 1State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.

Journal of the American Chemical Society
|November 29, 2021
PubMed
まとめ

アミロイドベータ (Aβ) ペプチドのO- 糖化がアルツハイマー病 (AD) の進行に影響する. この研究は,特定のO-グリカンがAβの結合と分解をどのように変化させるかを明らかにし,ADの病原性に関する新しい洞察を提供します.

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