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Updated: Oct 11, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

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全身マウスのNLRP3構造制御経路の活性化により明らかにされたNLRP3ケージ

Liudmila Andreeva1, Liron David1, Shaun Rawson2

  • 1Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA.

Cell
|December 3, 2021
PubMed
まとめ

NACHT,レウシンリッチリピート (LRR),およびピリン領域を含むタンパク質3 (NLRP3) は,細胞膜にダブルリングのケージを形成する. この構造は細胞損傷を感知し 炎症体の活性化を開始するのに不可欠で 慢性炎症の治療には新しい標的を提示します

キーワード:
NEK7 についてNLRP3 についてTGNTGNの分散クリオ・エム炎症ゾーム生まれつきの免疫トランス・ゴルギ・ネットワーク

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