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Updated: Oct 11, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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CAR T細胞機能障害におけるNK型のCAR T細胞変異

Charly R Good1, M Angela Aznar2, Shunichiro Kuramitsu2

  • 1Department of Cell and Developmental Biology, Penn Institute of Epigenetics, Perelman School of Medicine, Philadelphia, PA 19104, USA.

Cell
|December 3, 2021
PubMed
まとめ

化学抗原受容体 (CAR) T細胞治療は,固体腫瘍に対して有望である. 研究者らは,SOX4とID3をターゲットにすることで,CAR T細胞の枯渇を防止し,治療効果を向上させることがわかった.

キーワード:
CAR T細胞ID3 についてNK型のT細胞SOX4 についてT細胞機能障害T細胞の枯渇癌について細胞移植療法免疫学について免疫療法臓がん単細胞RNA-seq

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