腸内微生物群は,喫煙を中止した後のマウスの体重増加を調節する
Leviel Fluhr1, Uria Mor1, Aleksandra A Kolodziejczyk1
1Immunology Department, Weizmann Institute of Science, Rehovot, Israel.
Nature
|December 9, 2021
まとめ
禁煙による体重増加は 腸内微生物群の変化と 喫煙煙の代謝物によって引き起こされます 微生物群の回復は 体重増加を制御し 禁煙の成功を向上させるのに役立ちます
科学分野:
- 微生物群の研究
- メタボロミクス
- 禁煙の科学
背景:
- 世界中で予防可能な死因の"つは 喫煙です
- 禁煙による体重増加 (SCWG) は 禁煙の大きな障害です
- 現存する研究によると,SCWGはカロリー摂取を制御した状態でも発生します.
研究 の 目的:
- SCWGにおける腸内微生物と煙の代謝物の役割を調査する.
- SCWGの管理と禁煙の改善のための潜在的な治療目標を探求する.
主な方法:
- マウスモデルを使って 喫煙と禁煙が腸内微生物に与える影響を研究しました
- 微生物を枯渇させるための抗生物質を投与し 便の微生物移植を行いました
- コリン,ディメチルグリシン,N-アセチルグリシンを含む代謝経路を分析した.
主要な成果:
- 喫煙と禁煙は,喫煙代謝産物に関連した腸内障害を引き起こす.
- 微生物の枯渇はSCWGを予防し,移植は体重増加を引き起こした.
- SCWGは,コリンをジメチルグリシンに変換し,エネルギー収穫を増やし,N-アセチルグリシンを枯渇させます.
結論:
- 腸内微生物群は SCWGを媒介する上で重要な役割を果たします
- 微生物群に依存する代謝変化,特にコレンの代謝産物に関与する代謝変化が体重増加を促します.
- 微生物群とその代謝産物をターゲットにすることで 禁煙支援と代謝健康改善の 戦略が生まれます
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