Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

4.3K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
4.3K
Enteric Nervous System: Regulation of GI Motor Activity01:11

Enteric Nervous System: Regulation of GI Motor Activity

896
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
896
Functional Brain Systems: Reticular Formation01:13

Functional Brain Systems: Reticular Formation

2.9K
The reticular formation is a complex network of gray and white matter located within the brainstem extending from the medulla to the midbrain.
Within the reticular formation, there are several distinct nuclei that can be classified into three broad categories. The Raphe nuclei are located along the midline of the brainstem. They are primarily known for their role in synthesizing and releasing serotonin, a neurotransmitter involved in regulating mood, appetite, sleep, and circadian rhythms. The...
2.9K
Brainstem: Control Centers of Medulla01:21

Brainstem: Control Centers of Medulla

2.5K
The medulla oblongata is a crucial part of the brainstem responsible for controlling various autonomic and involuntary functions. It contains several nuclei, including the olivary, cuneate, gracile, and solitary nuclei.
Olivary Nucleus
The olivary nucleus, or inferior olivary nucleus, is located within the ventrolateral part of the medulla oblongata. It is primarily involved in motor coordination and motor learning. The olivary nucleus receives input from the spinal cord, cerebellum, and motor...
2.5K
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

3.3K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
3.3K
Neural Circuits01:25

Neural Circuits

1.8K
Neural circuits and neuronal pools are two of the main structures found in the nervous system. Neural circuits are networks of neurons that work together to carry out a specific task or process. They consist of interconnected neurons and glial cells, which provide structural and metabolic support.
Neuronal pools are collections of nerve cells with similar functions and interact through chemical and electrical signals. These pools include both interneurons (the central neural circuit nodes that...
1.8K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

MODELING TRAJECTORIES USING FUNCTIONAL LINEAR DIFFERENTIAL EQUATIONS.

The annals of applied statistics·2025
Same author

Genetically identified amygdala-striatal circuits for valence-specific behaviors.

Nature neuroscience·2021
Same author

A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.

Cell·2020
Same author

Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution.

Science (New York, N.Y.)·2019
Same author

Plants' use of different nitrogen forms in response to crude oil contamination.

Environmental pollution (Barking, Essex : 1987)·2010
Same author

Overexpression of p35 in Min6 pancreatic beta cells induces a stressed neuron-like apoptosis.

Journal of the neurological sciences·2010

関連する実験動画

Updated: Oct 10, 2025

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
10:05

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Published on: September 16, 2015

14.5K

遺伝的に定義されたインスラ・脳幹回路が 動機付けの活力を選択的に制御する

Hanfei Deng1, Xiong Xiao1, Tao Yang1

  • 1Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Cell
|December 10, 2021
PubMed
まとめ

前側の島皮質 (aIC) はFezf2ニューロンを通して動機付けの活力を伝達し,需要を求める行動に影響を与えます. この回路は 努力とドーパミンの放出を制御しますが 味覚や摂取を制御しません

キーワード:
Fezf2 についてNTS についてalC について前部島皮質ドーパミン努力するイメージング動機づけニュクレウス・トラクタス・ソリタリーオプトジェネティクスピラミッド管の神経細胞活力

さらに関連する動画

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
11:02

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

23.8K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K

関連する実験動画

Last Updated: Oct 10, 2025

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
10:05

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Published on: September 16, 2015

14.5K
Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
11:02

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning

Published on: August 21, 2015

23.8K
Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
09:29

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods

Published on: August 4, 2022

2.3K

科学分野:

  • 神経科学
  • 行動神経科学
  • 意思決定

背景:

  • 前側の島皮質 (aIC) は行動制御に不可欠ですが,その正確な神経機構は完全に理解されていません.
  • AIC内のピラミッド管ニューロンは,認知および動機付けのプロセスに関与しています.

研究 の 目的:

  • AICが動機付けの活力とニーズ探しの行動を制御する神経機構を解明する.
  • 動機付けられた行動の調節に関与する特定のニューロン集団と回路を特定する.

主な方法:

  • aIC (aICFezf2) で Fezf2 を発現するニューロンを特定し,標的にするために遺伝的ラベルを使用した.
  • ニューロンの活動とaICからNucleus tractus solitarii (NTS) への回路の投影を調査した.
  • 行動,ドーパミンの放出,消費を制御するaIC → NTS回路の役割を調べた.

主要な成果:

  • aICFezf2ニューロンは,NTSへの投影を通して,動機付けの活力を発信し,必要性を求める行動を活性化します.
  • 学習によって得られたaICFezf2およびNTSニューロンの予期的な活動は,ホメオスタティックなニーズに対する知覚価値と行動活力をコードします.
  • aIC → NTS回路は,学習した行動と必要性によって,精力,努力,および線状ドーパミンの放出を選択的に制御します.
  • aICFezf2ニューロンは 味やバレンスを表さないし サーキットは 強化や総消費を 駆動しません

結論:

  • aIC → NTS回路の動機付け活力を制御する特定の機能を特定した.
  • ドーパミンの信号を上から下へと調節することで モチベーションが部分的に促進されていることを示唆している.
  • 動機付けられた行動を調節するためのaICにおける特定のニューロン集団の役割を強調する.