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Updated: Oct 10, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
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Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

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ポリサブスティテッドビサイクロ[1.1.0]ブタンの合成と応用

Ryan E McNamee1, Amber L Thompson1, Edward A Anderson1

  • 1Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, U.K.

Journal of the American Chemical Society
|December 14, 2021
PubMed
まとめ

誘導メタリングを用いた代替ビサイクロ[1.1.0]ブタン (BCB) の合成のための新しい方法を開発しました. このアプローチは,後期的な機能化を可能にし,多様なBCB構成要素を作り,ビサイクロ[1.1.1]ペンタンの形成に関する新しい洞察を提供します.

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Disubstituted Cyclohexanes: cis-trans Isomerism

Depending upon the different spatial orientation of the substituents, the disubstituted cycloalkanes exhibit two types of stereoisomers. The cis isomers have the substituents on the same side of the ring, whereas the trans isomers have the substituents on the opposite sides. These stereoisomers exhibit different physical properties and cannot be interconverted without breaking the carbon-carbon bonds.
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