米国成人の保存比率障害スピロメトリーと臨床結果との関連
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まとめ
この要約は機械生成です。保存比低下スピロメトリー (PRISm) は,米国成人における死亡率増加と呼吸器系および心血管疾患の不良結果と関連しています. これらの健康問題との因果関係に関するさらなる調査が必要である.
科学分野
- 肺医学
- 流行病学について
- 公衆衛生
背景
- 慢性肺疾患は死と病気の主な原因です
- 閉塞のない肺の容量の減少という状態である保存比障害スピロメトリー (PRISm) の臨床結果は,COPDと比較してよく理解されていません.
研究 の 目的
- 米国の成人の集団におけるPRISmの流行,関連因子,および臨床結果を決定する.
主な方法
- 国立心臓,肺,血液研究所 (NHLBI) のグループコホート研究から得られたデータを活用し,有効な基礎肺機能を持つ53,000人以上の参加者を対象とした.
- 参加者は,FEV1:FVC比率とFEV1に基づいてPRISm,阻害性スピロメトリー,および正常スピロメトリーグループに分類されます.
- 調整されたポアソンとコックスの比例リスクモデルを用いて,全因死亡率,呼吸器疾患,冠動脈疾患 (CHD) の関連性を分析した.
主要な成果
- 参加者の8. 5%がPRISmを患っており,肥満,体重不足,女性の性別,喫煙と関連していました.
- PRISmは,通常のスピロメトリーと比較して,全因死亡率 (HR 1. 50),呼吸道死亡率 (HR 1. 95),心臓病死亡率 (HR 1. 55),呼吸道イベント (HR 1. 90) および心臓病イベント (HR 1. 30) のリスクの増加と有意に関連していました.
結論
- 多くの米国では,PRISmは統計的に有意な死亡率の増加と心血管および呼吸器系の不良結果と関連しています.
- PRISmとこれらの有害な健康結果の間の潜在的な因果関係を調査するためにさらなる研究が推奨されています.
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