関連する実験動画

Updated: Oct 10, 2025

An In Vitro Assay to Detect tRNA-Isopentenyl Transferase Activity
07:46

An In Vitro Assay to Detect tRNA-Isopentenyl Transferase Activity

Published on: October 8, 2018

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TTNの読み取りフレームの修復 トンカションの変種はタイトンの量と機能を復元する

Robert Romano1, Shahnaz Ghahremani2, Talia Zimmerman2

  • 1University of Connecticut Health Center, Farmington (R.R., F.A.L., A.M.P., J.T.H.).

Circulation
|December 14, 2021
PubMed
まとめ

ティチン切断変種 (TTNtvs) は拡張性心筋病 (DCM) を引き起こします. A帯のTTNtvsはより病原性であり,サルコメアの機能とミオフィブリロゲネシスを損なう. CRISPRの遺伝子編集は TTNtvsの潜在的な治療戦略を提供します

キーワード:
CRISPRによる読み取りフレーム修復TTN について拡大心筋病titinの切り取りのバリエーション

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