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Updated: Oct 9, 2025

Adoptive Transfer of IL-33-Stimulated Macrophages into Bleomycin-Induced Mouse Models to Study Their Effect on Idiopathic Pulmonary Fibrosis In Vivo
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SARS-CoV-2 感染症は,プロフィブロティックなマクロファージ反応と肺線維症を引き起こす

Daniel Wendisch1, Oliver Dietrich2, Tommaso Mari3

  • 1Charité - Universitätsmedizin Berlin, Department of Infectious Diseases and Respiratory Medicine, Charité, Universitätsmedizin Berlin, Berlin, Germany.

Cell
|December 16, 2021
PubMed
まとめ

重度のCOVID-19は,プロフィブロティックマクロファージを誘発し,肺線維症を引き起こすことで,急性呼吸器障害症候群 (ARDS) を引き起こします. この研究は,SARS-CoV-2がマクロファージにおけるこれらの線維反応を直接誘発することを明らかにしています.

キーワード:
ARDS についてコロナウイルスIPF についてSARS-CoV-2について繊維症肺についてマクロファージモノサイトプロテオミクス肺繊維症単細胞トランスクリプトミクス

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