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Updated: Oct 9, 2025

Assessing Cardiomyocyte Subtypes Following Transcription Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts
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Published on: March 22, 2017

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PRDM16は,左心室内のコンパクト心筋筋細胞のアイデンティティを維持するために必要なコンパクト心筋濃縮転写因子です

Tongbin Wu1, Zhengyu Liang2, Zengming Zhang1

  • 1Department of Medicine (T.W., Z.Z., C.L., Y.G., K.L.P., S.M.E., J.C.), University of California San Diego, La Jolla.

Circulation
|December 17, 2021
PubMed
まとめ

PRDM16欠乏症は,コンパクト心筋細胞の特異性を破壊することによって,左心室非圧縮性心筋病 (LVNC) を引き起こします. この研究は,LV室の成長と成熟の調節におけるPRDM16の役割を明らかにし,LVNCにおけるLV感受性を説明する.

キーワード:
RNA-Seq について心筋病クロマチンの免疫降水配列遺伝子発現の調節トランスクリプトーム

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