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Updated: Oct 9, 2025

Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry
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Analyzing Protein Dynamics Using Hydrogen Exchange Mass Spectrometry

Published on: November 29, 2013

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Hsp90-Hsp70-Hop-GRの構造は,Hsp90クライアントロードメカニズムを明らかにする

Ray Yu-Ruei Wang1, Chari M Noddings1, Elaine Kirschke1

  • 1Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA.

Nature
|December 23, 2021
PubMed
まとめ

この研究は,コチャペロンホップを含む分子チャペロンHsp70およびHsp90が,グルココルチコイド受容体 (GR) を負荷し無効化する分子メカニズムを明らかにしています. この発見は,シェーパーロン媒介のクライアントタンパク質の再構築の完全な理解を提供します.

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