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関連する概念動画

Polygenic Traits01:18

Polygenic Traits

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When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
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Pleiotropy01:33

Pleiotropy

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Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
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Incomplete Dominance01:43

Incomplete Dominance

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Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
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General Transcription Factors01:30

General Transcription Factors

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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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関連する実験動画

Updated: Oct 7, 2025

Application of DNA Fingerprinting using the D1S80 Locus in Lab Classes
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肢体 の 発達 に 関する 遺伝子 は,人間 の 指紋 の 様式 の 違い を 引き起こす

Jinxi Li1, James D Glover2, Haiguo Zhang3

  • 1State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, and Human Phenome Institute, Fudan University, Shanghai 200438, PRC; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, PRC.

Cell
|January 7, 2022
PubMed
まとめ

遺伝的要因が 指紋のパターンに影響します 研究者らは指紋の種類と相関関係に関連した特定の遺伝子位置 (ロキ) を発見し,これらのユニークな人間の特徴を形作る際に 肢体の発達遺伝子の役割を強調した.

キーワード:
EVI1 について指紋のパターン遺伝学全ゲノム関連研究手足の発達トランス民族メタ解析

さらに関連する動画

Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
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Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
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関連する実験動画

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Whole-mount Immunohistochemical Analysis for Embryonic Limb Skin Vasculature: a Model System to Study Vascular Branching Morphogenesis in Embryo
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Chicken Recombinant Limbs Assay to Understand Morphogenesis, Patterning, and Early Steps in Cell Differentiation
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科学分野:

  • 遺伝学
  • 発達生物学
  • 人間 の 変化

背景:

  • フィンガープリントの変異は長い間認識されてきましたが,メカニズムレベルでは十分に理解されていません.
  • 過去の研究では 指紋パターンの決定因子に関する 総合的な遺伝的洞察が欠けていました

研究 の 目的:

  • 指紋の種類とパターンに関連した遺伝的位置を特定する.
  • 皮膚文字の変異における EVI1 などの特定の遺伝子の役割を調査する.
  • 指紋のパターンと 手の比例の遺伝的相関を調べる

主な方法:

  • 全ゲノム関連研究 (GWAS) は漢族のコホートで実施された.
  • 関連した余分な位置を特定するために,トランス民族的なメタ分析が行われました.
  • 候補遺伝子の機能を調査するために,遺伝子発現分析とマウスモデルを使用した.

主要な成果:

  • ハン族のコホートで指紋型に関連した18の位置が特定されました.
  • EVI1遺伝子の近くの変異は,マウスの調整活動と皮膚文字パターンの変化と関連していた.
  • トランス民族的なメタアナリシスで 43の指紋関連ロキュアが特定され, 肢体の発達経路が強化された.
  • 指紋のパターンと 手の比例の間の遺伝的相関が 見つかりました

結論:

  • 肢体の発達遺伝子は 指紋パターンの決定に 重要な役割を果たします
  • この研究は指紋のパターンの 相関関係に関する 遺伝的根拠を提供する.
  • EVI1は皮膚文字のパターニングに関与しており,表現のダイナミクスは,肢と指の形づくりの役割を示唆している.