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Updated: Oct 7, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
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Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

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複雑な分子の末期メチル化のための電気化学C ((sp3) -H酸化の探索

Luiz F T Novaes1, Justin S K Ho1, Kaining Mao1

  • 1Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14850, United States.

Journal of the American Chemical Society
|January 11, 2022
PubMed
まとめ

薬剤化学者は新しい電気化学的方法を使って 複雑な薬の分子にメチル群を 選択的に加えることができます この"マジックメチル"戦略は 合成を簡素化し 薬の発見を加速します

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Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...
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Oxidative reactions are pivotal in metabolizing numerous compounds, including pharmaceutical drugs. These reactions often occur in carbon-heteroatom systems, such as carbon-nitrogen, carbon-sulfur, and carbon-oxygen.
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